Found 15 matching trials
Radiolabelled IV and Oral Metabolism Study of F901318 PHASE1 Open label radiolabelled metabolism study of intravenous and oral solution ...
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Quotient Clinical
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Absorption, Metabolism and Excretion of 14C-olorofim in Man PHASE1 Single-centre, open-label, non-randomised, single dose study in 2 cohorts o...
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PRA Health Sciences
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A Phase I Study to Assess the Pharmacokinetics of Olorofim in Subjects With Hepatic Impairment PHASE1 A single oral dose study to investigate the PK and safety of olorofim in mi...
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Orange County Research Centre
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Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects PHASE1 A Phase I, open label study evaluating safety, tolerability and pharmacokin...
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Covance Clinical Research Unit
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Safety and Pharmacokinetics of Oral F901318 (Fluconazole and Posaconazole) IN Aml Leukaemia PHASE1 Non-randomized, multi-centre, open label, uncontrolled, multiple dose, phas...
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Multiple Locations
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Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe PHASE1 Open label evaluation of potential interaction of F901318 with cytochrome P...
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Hammersmith Medicines Research
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Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options PHASE2 A study to evaluate olorofim (F901318) for the treatment of invasive fungal...
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Valley Fever Institute at Kern Medical Center
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Single Ascending Oral Dose Study of F901318 PHASE1 Double blind, placebo controlled, ascending single oral dose, sequential gr...
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A Phase II Randomized Study to Evaluate Measures for Endpoint Derivation in Patients With Progressive or Refractory Disseminated Coccidioidomycosis (DCM ) Treated With Olorofim Plus Baseline SOC or Placebo Plus Baseline SOC PHASE2 The purpose of this study is to test measurement tools (questionnaire about...
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Multiple Locations
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Study of Potential for Interaction of Fluconazole With F901318 PHASE1 This will be an open label study in two parts. In the first part, F901318 (...
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